The alpha2 Gene alleles of the platelet collagen receptor integrin alpha2 beta1 in Turkish children with cerebral infarct.

Akar N., Duman T., Akar E., Deda G., Sipahi L.

Thrombosis research, cilt.102, sa.2, ss.121-3, 2001 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 102 Sayı: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0049-3848(01)00228-6
  • Dergi Adı: Thrombosis research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.121-3
  • Anahtar Kelimeler: pediatric stroke, integrin gene, ALPHA(2)BETA(1) INTEGRIN, CODING SEQUENCE, ISCHEMIC STROKE, GLYCOPROTEIN-IA, RISK FACTOR, MUTATION, POLYMORPHISMS, DEFICIENCY, CHILDHOOD, DISORDER
  • Ankara Üniversitesi Adresli: Evet

Özet

The possible role of point mutations in the platelet integrin alpha2 beta1 gene in Turkish children with ischemic stroke was evaluated in this study. The case-control study included 44 pediatric patients with cerebral infarct (age range, 10 months to 18 years) and 96 healthy unrelated individuals. Genotyping was performed according to previously described methods. Distribution of the three haplotypes were 36.4%, 45.3%, 10.4% and 31.8%, 50.0%, 13.6% for the controls and the patients, respectively. A new fourth haplotype was found which was 7.8% and 4.5% respectively. Our data indicated that these haplotypes are not risk factors in pediatric stroke group. (C) 2001 Elsevier Science Ltd. All rights reserved.