Vanishing bile duct syndrome after allogeneic bone marrow transplantation: Is it the end of the road?

Bakanay S. M., Ugur Bilgin A., Bektas M., İDİLMAN R., Erden E., Arat M., ...Daha Fazla

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.24, sa.4, ss.359-362, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4318/tjg.2013.0604
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.359-362
  • Anahtar Kelimeler: Hematopoietic cell transplantation, hepatic GVHD, vanishing bile duct syndrome, VERSUS-HOST-DISEASE, STEM-CELL TRANSPLANTATION, LIVER-TRANSPLANTATION, URSODEOXYCHOLIC ACID, THERAPY, COMPLICATIONS, SURVIVAL
  • Ankara Üniversitesi Adresli: Evet

Özet

In this paper, we report the case of a 19-year-old male patient who presented with lymphoblastic phase of chronic myeloid leukemia and received an allogeneic bone marrow transplant from his cousin. The patient experienced severe, steroid-refractory acute graft-versus-host disease of skin, gastrointestinal tract and liver that required further immunosuppression. However, hepatic graft-versus-host disease was complicated with vanishing bile duct syndrome, characterized by progressive destruction of small intrahepatic bile ducts, which was refractory to all available therapies and eventually led to end-stage liver disease. The pathogenesis and treatment of graft-versus-host disease after allogeneic hematopoietic cell transplantation is discussed with an emphasis on liver transplantation for intractable hepatic graft-versus-host disease.