Role of ATP-dependent K channels in the effects of erythropoietin in renal ischaemia injury
INDIAN JOURNAL OF MEDICAL RESEARCH, cilt.141, ss.807-815, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 141
- Basım Tarihi: 2015
- Doi Numarası: 10.4103/0971-5916.160713
- Dergi Adı: INDIAN JOURNAL OF MEDICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.807-815
- Anahtar Kelimeler: Diazoxide, erythropoietin, glinbenclamide, hypoxia inducible factor-1 alpha, KATP channels, REPERFUSION INJURY, ISCHEMIA/REPERFUSION INJURY, SIGNALING PATHWAYS, MECHANISMS, KIDNEY, CARDIOPROTECTION, INFLAMMATION, PROTECTS, CELLS, HEART
- Ankara Üniversitesi Adresli: Evet
Özet
Background & objectives: Erythropoietin (EPO) has cytoprotective and anti-apoptotic effects in pathological conditions, including hypoxia and ischaemia-reperfusion injury. One of the targets to protect against injury is ATP-dependent potassium (KATP) channels. These channels could be involved in EPO induced ischaemic preconditoning like a protective effect. We evaluated the cell cytoprotective effects of EPO in relation to KATP channel activation in the renal tubular cell culture model under hypoxic/normoxic conditions.