Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model

EVLİYAOĞLU S. O., BERBEROĞLU M., Adiyaman P., AYCAN Z., Oecal G.

TURKISH JOURNAL OF PEDIATRICS, vol.49, no.2, pp.165-170, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 2
  • Publication Date: 2007
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.165-170
  • Keywords: premature pubarche, insulin resistance, INTRAUTERINE GROWTH, FASTING GLUCOSE, CHILDREN, HYPERINSULINEMIA, SENSITIVITY, ADRENARCHE, HISTORY, WEIGHT, RATIO
  • Ankara University Affiliated: Yes

Abstract

Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n=19; mean age=6.93 +/- 1.78) as compared to age- and Tanner stage-matched controls (n=10; mean age=7.55 +/- 1.32) using indirect insulin resistance parameters. Two groups were compared by means of oral glucose tolerance test (OGTT), indirect insulin resistance (IR) parameters [homeostasis assessment (HOMA) models: HOMA-IR, glucose/insulin (G/I)] and serum lipid profiles. In the girls with premature pubarche, mean baseline insulin level and HOMA-IR value were significantly higher and G/I ratio was lower than in the control group. IR was observed in 42.1% and in 31.6% according to HOMA-IR value and G/I ratio, respectively. Even at diagnosis, IR was increased in a significant portion of the girls with premature pubarche.