Comutagenesis-I: The in vitro metabolism of 2-amino-3-methylpyridine

ALTUNTAŞ T., Manson D., Zhao K., Gorrod J. W.

Anticancer Research, cilt.17, sa.5 A, ss.3485-3491, 1997 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 5 A
  • Basım Tarihi: 1997
  • Dergi Adı: Anticancer Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3485-3491
  • Anahtar Kelimeler: 2-amino-3-methylpyridine, Comutagenesis, Metabolism, Oxidative metabolites, Synthesis of potential metabolites
  • Ankara Üniversitesi Adresli: Evet

Özet

The metabolism of the comutagen 2-amino-3-methylpyridine had been studied in vitro using rat and rabbit hepatic preparations. 2-Amino-3-methylpyridine-N-oxide, 2-amino-3-hydroxymethylpyridine and 2-amino-5-hydroxy-3-methylpyridine were formed by both rat and rabbit hepatic preparations. No evidence was obtained for the formation of the corresponding 2-hydroxylamine, 2-nitroso, 2-nitro-3-methylpyridine or their condensation products, i.e. azo, azoxy or hydrazo. The results are discussed in relation to the possible mechanism of action of the substrate.