The cellular immunity and oxidative stress markers in early pregnancy loss

Daglar K., Biberoglu E., Kirbas A., Dirican A. O., Genc M., Avci A., ...Daha Fazla

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.29, sa.11, ss.1840-1843, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 11
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/14767058.2015.1064886
  • Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1840-1843
  • Anahtar Kelimeler: Adenosine deaminase, catalase, glutathione peroxidase, malondialdehyde, miscarriage, spontaneous abortion, REGULATORY T-CELLS, ADENOSINE-DEAMINASE ACTIVITY, TOLERANCE, WOMEN
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: We investigated whether changes in cellular immunity and oxidative stress in pregnancy have any association with spontaneous miscarriage.Material and methods: Circulating adenosine deaminase (ADA) activity as a marker of cellular immunity and malondialdehyde (MDA) and catalase (CAT), glutathione peroxidase (GPx) as markers of T lymphocyte activation and parameters of oxidative stress and antioxidant defense were compared between 40 women with early pregnancy loss and another 40 women with ungoing healthy pregnancy.Results: Women with miscarriage had higher serum ADA and GPx levels when compared with women with normal pregnancy (p=0.034 and p<0.001, respectively). Although serum MDA level was slightly higher in women with miscarriage, the difference was not significant (p=0.083). CAT levels were alike in both groups.Conclusion: We have demonstrated an increased cellular immunity and perhaps a compensated oxidative stress related to increased antioxidant activation in women with early spontaneous pregnancy loss.