The Effects of Sodium Arsenite on Glutathione and Malondialdehyde Levels in Mice Tissues

Dip A., Saygi Ş., ÇEÇEN S., Soylemezoglu T.

Acta Pharmaceutica Turcica, cilt.45, sa.3, ss.187-195, 2003 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 3
  • Basım Tarihi: 2003
  • Dergi Adı: Acta Pharmaceutica Turcica
  • Derginin Tarandığı İndeksler: Scopus, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.187-195
  • Anahtar Kelimeler: Glutathione, Lipid peroxidation, Malondialdehyde, Sodium arsenite
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, the oxidative damage of sodium arsenite (NaAsO2)) was investigated by measuring the malondialdehyde (MDA) and glutathione (GSH) levels. NaAsO2 was administered Swiss Albino mice (35 mg/kg) and sacrificed after one hour. MDA and GSH levels were determined in liver, kidney, brain and heart tissues by UV-Spectrophotometric methods. After NaAsO 2 treatment MDA levels decreased in liver, brain and kidney (p<0.001), on the other hand, increased significantly in heart tissues (p<0.01). No alteration was observed in liver and kidney GSH levels, however, NaAsO2 caused significant depletion in GSH in both heart and brain (p<0.01) tissues.