Akademik Veri Yönetim Sistemi
CYTOKINE, cilt.12, sa.7, ss.1151-1155, 2000 (SCI-Expanded)
We aimed to investigate the daily variations of serum granulocyte-macrophage colony-stimulating factor (GM-CSF) levels and to correlate them with peripheral blood cells counts, Venous blood samples from eleven healthy volunteers were taken four times a day, being at 08:00, 14:00, 20:00 and 02:00h and serum GM-CSF levels measured by ELISA, We could not find a significant overall difference among GM-CSF levels at four different times of the day using the Friedman test, On the other hand, serum GM-CSB levels at night (20:00h) were found to be significantly increased when compared to the morning levels (08:00h) using the Wilcoxon test (P=0,022), The levels of lymphocytes and white blood cells (WBCs) at 20:00h mere also higher than the morning levels (08:00h) as expected, While there was a strong relationship between the morning levels of GM-CSF (08:00h) and all measurements of peripheral blood cells during the day, the levels of GM-CSF measured at 02:00, 14:00 and 20:00h were found to be significantly correlated with only the WBC levels, It was concluded that there may be a significant difference between morning and night levels of GM-CSF and morning levels of GM-CSF may be more important in the regulation of WBC counts during the day, These variations warrant further studies about diurnal rhythms of haematopoiesis chronotherapy with CSFs. (C) 2000 Academic Press.