LC with electrochemical detection. Recent application to pharmaceuticals and biological fluids

Oezkan S. A.

Chromatographia, cilt.66, sa.SUPPL. 1, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 66 Sayı: SUPPL. 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1365/s10337-007-0223-9
  • Dergi Adı: Chromatographia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: column liquid chromatography, electrochemical detection, biological media, pharmaceutical dosage forms, PERFORMANCE LIQUID-CHROMATOGRAPHY, SOLID-PHASE EXTRACTION, GLASSY-CARBON ELECTRODE, AMPEROMETRIC DETECTION, HUMAN-PLASMA, COULOMETRIC DETECTION, HPLC METHOD, MONOAMINE NEUROTRANSMITTERS, QUANTITATIVE-DETERMINATION, DIAMOND ELECTRODES
  • Ankara Üniversitesi Adresli: Evet

Özet

Many pharmaceutical compounds have electroactive groups and are readily measurable and detectable by liquid chromatography with electrochemical detection (LC-EC). LC-EC techniques have many advantages as measurement systems and new materials have been developed for working electrodes. Use of modern electroanalytical techniques for detection in LC of pharmaceutical compounds is discussed in this review. EC detection in LC often results in improved selectivity and detection limits for electroactive pharmaceutical compounds. Selected literature on the determination of pharmaceutical compounds in their dosage forms and in biological samples are reported. © 2007 Friedr. Vieweg & Sohn Verlag/GWV Fachverlage GmbH.