Fas-mediated pathway and apoptosis in normal, hyperplastic, and neoplastic endometrium

Atasoy, P; Bozdogan, O; Erekul, S; Bozdogan, N; Bayram, M

doi:10.1016/s0090-8258(03)00411-6

Fas-mediated pathway and apoptosis in normal, hyperplastic, and neoplastic endometrium

Atasoy P., Bozdogan O., Erekul S., Bozdogan N., Bayram M.

GYNECOLOGIC ONCOLOGY, cilt.91, sa.2, ss.309-317, 2003 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 91 Sayı: 2
Basım Tarihi: 2003
Doi Numarası: 10.1016/s0090-8258(03)00411-6
Dergi Adı: GYNECOLOGIC ONCOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.309-317
Anahtar Kelimeler: Fas, caspase-3 (CPP32), M30, apoptosis, endometrial carcinoma, endometrial hyperplasia, DOWN-REGULATION, DIFFERENTIAL EXPRESSION, LIGAND EXPRESSION, BCL-2, PROLIFERATION, CARCINOMA, CASPASE-3, PATTERNS, BENIGN, MARKER
Ankara Üniversitesi Adresli: Hayır

Özet

Introduction. Abnormalities in the control of cell proliferation and apoptosis have been suggested to contribute to the development and progression of neoplasia. There are at least two pathways that activate apoptosis. The first is a mitochondria-dependent route governed by bcl-2 family proteins. The second is a parallel mechanism which involves the activation of a group of tumor necrosis factor (TNF) receptors, such as Fas.