Fas-mediated pathway and apoptosis in normal, hyperplastic, and neoplastic endometrium

Atasoy, P; Bozdogan, O; Erekul, S; Bozdogan, N; Bayram, M

doi:10.1016/s0090-8258(03)00411-6

Fas-mediated pathway and apoptosis in normal, hyperplastic, and neoplastic endometrium

Atasoy P., Bozdogan O., Erekul S., Bozdogan N., Bayram M.

GYNECOLOGIC ONCOLOGY, vol.91, no.2, pp.309-317, 2003 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 91 Issue: 2
Publication Date: 2003
Doi Number: 10.1016/s0090-8258(03)00411-6
Journal Name: GYNECOLOGIC ONCOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.309-317
Keywords: Fas, caspase-3 (CPP32), M30, apoptosis, endometrial carcinoma, endometrial hyperplasia, DOWN-REGULATION, DIFFERENTIAL EXPRESSION, LIGAND EXPRESSION, BCL-2, PROLIFERATION, CARCINOMA, CASPASE-3, PATTERNS, BENIGN, MARKER
Ankara University Affiliated: No

Abstract

Introduction. Abnormalities in the control of cell proliferation and apoptosis have been suggested to contribute to the development and progression of neoplasia. There are at least two pathways that activate apoptosis. The first is a mitochondria-dependent route governed by bcl-2 family proteins. The second is a parallel mechanism which involves the activation of a group of tumor necrosis factor (TNF) receptors, such as Fas.