Akademik Veri Yönetim Sistemi
Drug Development and Industrial Pharmacy, cilt.23, sa.6, ss.589-594, 1997 (SCI-Expanded)
The mechanical strength of the granules is defined by the friability index (FI). This index describes the condition at the end of a certain time period. However, the mixing process during industrial manufacturing displays a continuity that changes as a function of time. In this study, the mechanical strength of a briquette granule composed of a mixture of lactose, microcrystalline cellulose, and microfine cellulose, and obtained by the dry granulation (slugging) method was examined as a function of its duration of friability. In addition, the effect of the length of friability period on the physicopharmaceutical and compression properties of the briquette granules was observed. It was found that the friability event in the briquette granules occurs as an interparticular milling instead of as a breakdown of the binding bridges as in the wet granulation method, and that compressibility and other properties change to interfere with the validity of the process.