Infertility in a man with oligoasthenoteratozoospermia associated with nonrobertsonian translocation t(9;15)(p10;q10)

Aydos S. E., Tukun A.

Fertility and Sterility, cilt.86, sa.4, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86 Sayı: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.fertnstert.2006.02.124
  • Dergi Adı: Fertility and Sterility
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Nonrobertsonian translocation, male infertility, chromosome banding
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: To analyze an unusual nonrobertsonian translocation t(9;15)(p10;q10) found in an infertile man with oligoasthenoteratozoospermia who had a normal phenotype. Design: Case report with a review of scientific literature. Setting: Academic research environment. Patient(s): Infertile man with oligoasthenoteratozoospermia but otherwise apparently healthy. Intervention(s): Peripheral blood lymphocytes were obtained for karyotyping, and metaphases were studied by the GBG fluorescence in situ hybridization (FISH) procedure. Main Outcome Measure(s): Physical examination, semen analysis, GBG banding, and FISH procedure. Result(s): The semen analysis revealed oligoasthenoteratozoospermia. The lymphocytic karyotype detected a translocation t(9;15)(p10;q10), and FISH procedure showed that the derived chromosome had a chromosome 15 centromere. Conclusion(s): The association of unusual translocation with male factor infertility was described. To our knowledge no such association has been described previously in men whose clinical manifestation is only infertility. © 2006 American Society for Reproductive Medicine.