Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not In primary tumours

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ÖZDAĞ SEVGİLİ H., Batley S., Forsti A., Iyer N., Daigo Y., Boutell J., ...Daha Fazla

BRITISH JOURNAL OF CANCER, cilt.87, sa.10, ss.1162-1165, 2002 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 87 Sayı: 10
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1038/sj.bjc.6600554
  • Dergi Adı: BRITISH JOURNAL OF CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1162-1165
  • Anahtar Kelimeler: P300, CBP, PCAF, mutations, epithelial cancers, PROTEIN, P300, GENE
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Hayır

Özet

In this study we screened the histone acetyltransferases CBP and PCAF for mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers. (C) 2002 Cancer Research UK.