Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not In primary tumours

ÖZDAĞ SEVGİLİ, HİLAL; Batley, SJ; Forsti, A; Iyer, NG; Daigo, Y; Boutell, J; Arends, MJ; Ponder, BAJ; Kouzarides, T; Caldas, C

doi:10.1038/sj.bjc.6600554

Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not In primary tumours

Atıf İçin Kopyala

ÖZDAĞ SEVGİLİ H., Batley S., Forsti A., Iyer N., Daigo Y., Boutell J., ...Daha Fazla

BRITISH JOURNAL OF CANCER, cilt.87, sa.10, ss.1162-1165, 2002 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 87 Sayı: 10
Basım Tarihi: 2002
Doi Numarası: 10.1038/sj.bjc.6600554
Dergi Adı: BRITISH JOURNAL OF CANCER
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1162-1165
Anahtar Kelimeler: P300, CBP, PCAF, mutations, epithelial cancers, PROTEIN, P300, GENE
Ankara Üniversitesi Adresli: Hayır

Özet

In this study we screened the histone acetyltransferases CBP and PCAF for mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers. (C) 2002 Cancer Research UK.