Neurodegenerative changes and apoptosis induced by intrauterine and extrauterine exposure of radiofrequency radiation

GÜLER ÖZTÜRK G., ÖZGÜR BÜYÜKATALAY E., KELEŞ H., TOMRUK A., VURAL S., Seyhan N.

JOURNAL OF CHEMICAL NEUROANATOMY, cilt.75, ss.128-133, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jchemneu.2015.10.006
  • Dergi Adı: JOURNAL OF CHEMICAL NEUROANATOMY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.128-133
  • Anahtar Kelimeler: Mobile phone, Apoptosis, DNA damage, 8-OhdG, Lipid peroxidation, TUNEL, RAT-BRAIN CELLS, OXIDATIVE STRESS, DNA-DAMAGE, PREGNANT RABBITS, IN-VITRO, ELECTROMAGNETIC-RADIATION, LIPID-PEROXIDATION, MELATONIN PROTECTS, REACTIVE OXYGEN, BLOOD-CHEMISTRY
  • Ankara Üniversitesi Adresli: Evet

Özet

Adverse health effects of radiofrequency radiation (RFR) on the ongoing developmental stages of children from conception to childhood are scientifically anticipated subject. This study was performed to identify the effects of global system for mobile communications (GSM) modulated mobile phone like RFR in 1800 MHz frequency on oxidative DNA damage and lipid peroxidation beside the apoptotic cell formation, using histopathological and immunohistochemical methods in the brain tissue of 1-month old male and female New Zealand White rabbits that were exposed to these fields at their mother's womb and after the birth. Oxidative DNA damage and lipid peroxidation levels were investigated by measuring the 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels, respectively. Histopathological changes were observed using by hematoxylin and eosin (HE) staining. Apoptotic cells were detected in the examined organs by terminal deoxynucleotidyl transferasemediated dUTP nick end-labeling (TUNEL) staining.