Antiischemic effect of ZK-118.182 in rabbits: A comparative study with iloprost

Akarsu E. S., Keskil S., Kaymaz M., Uysal S., Ceviker N., Ataoglu O., ...More

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, vol.20, no.4, pp.339-342, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 4
  • Publication Date: 1998
  • Doi Number: 10.1358/mf.1998.20.4.469482
  • Journal Name: METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.339-342
  • Keywords: PGD(2), cerebral ischemia, ZK-118.182, iloprost, endothelin-1, STABLE PROSTAGLANDIN-D-2 ANALOG, BRAIN, ENDOTHELIN-1, VESSELS
  • Ankara University Affiliated: Yes

Abstract

The effects of ZK-118.182, a stable analogue of PGD(2), were evaluated in an endothelin-1-induced cerebral ischemia rabbit model. Ischemia was induced by endothelin-1 injection (0.25 ng bolus) into subcavian nr ten, and ischemic changes were assessed histologically by the number of ischemic neurons in the brain stem. ZK-118.182 (2 mu g/kg, bolus into subclavian artery) reduced the number of ischemic neurons when injected 20 min after endothelin-1 injection. Iloprost, a stable analogue of PGI(2), was also effective in reducing the number of ischemic neurons ill a dose of 0.5 mu g/kg (bolus into subclavian artery). The results suggested that ZK-118.182 has a potent antiischemic effect which is comparable to that of iloprost in rabbits. (C) 1998 Prous Science. All rights reserved.