Synthesis and hypoglycaemic activity of some new flavone derivatives - Part 1: Flavonylsulphonylurea derivatives

Bozdag O., Verspohl E., Ertan R.

ARCHIV DER PHARMAZIE, cilt.332, sa.12, ss.435-438, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 332 Sayı: 12
  • Basım Tarihi: 1999
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.435-438
  • Anahtar Kelimeler: flavone, hypoglycaemic activity, flavonylsulphonylurea, LENS ALDOSE REDUCTASE, HYPOGLYCEMIC ACTIVITY, INHIBITION, PATHOGENESIS, NIDDM, RAT
  • Ankara Üniversitesi Adresli: Evet

Özet

A new series of flavonyl-3'-sulphonylurea derivatives (1-7) was prepared by reaction of several isocyanates with flavone-3'-sulpholamide (III). The prepared compounds were tested for their insulinotropic activities in INS-I cells. Compounds 1 and 4 were able to increase insulin release in the presence of 8.3 mM glucose pat least at the higher concentrations used.