Synthesis and hypoglycaemic activity of some new flavone derivatives - Part 1: Flavonylsulphonylurea derivatives

Bozdag O., Verspohl E., Ertan R.

ARCHIV DER PHARMAZIE, vol.332, no.12, pp.435-438, 1999 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 332 Issue: 12
  • Publication Date: 1999
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.435-438
  • Keywords: flavone, hypoglycaemic activity, flavonylsulphonylurea, LENS ALDOSE REDUCTASE, HYPOGLYCEMIC ACTIVITY, INHIBITION, PATHOGENESIS, NIDDM, RAT
  • Ankara University Affiliated: Yes

Abstract

A new series of flavonyl-3'-sulphonylurea derivatives (1-7) was prepared by reaction of several isocyanates with flavone-3'-sulpholamide (III). The prepared compounds were tested for their insulinotropic activities in INS-I cells. Compounds 1 and 4 were able to increase insulin release in the presence of 8.3 mM glucose pat least at the higher concentrations used.