Inhibition of DNA Topoisomerases by a Series of Benzoxazoles and their Possible Metabolites

Zilifdar F., Foto E., ERTAN BOLELLİ T., YILDIZ İ., Aki-Yalcin E., DİRİL N.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.15, sa.11, ss.1155-1162, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1570180815666180124143246
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1155-1162
  • Anahtar Kelimeler: Benzoxazole, benzamide, phenylacetamide, topoisomerase I, topoisomerase II, topoisomerase inhibitors, BIOLOGICAL EVALUATION, II INHIBITORS, DERIVATIVES, ANTICANCER, ANALOGS, BENZIMIDAZOLES, BENZOTHIAZOLE, MECHANISMS, APOPTOSIS, BINDING
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: A series of 2-substituted benzoxazoles and their possible metabolites, N-(2-hydroxy-4(or 5)-nitrophenyl)benzamides and phenylacetamides, which were previously synthesized by our group, were investigated for their inhibitory activities on both eukaryotic DNA topoisomerase I (Topo I) and II (Topo II).