Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome

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Gültuna S., Sandıkçı S. C., Kaplanoğlu H., Aydın F. N., Ateş F. S. Ö.

Archives of Rheumatology, cilt.37, sa.1, ss.40-48, 2022 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.46497/archrheumatol.2022.8838
  • Dergi Adı: Archives of Rheumatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.40-48
  • Anahtar Kelimeler: Atherosclerosis, cardiovascular disease, carotid intima-media thickness, lipoprotein associated phospholipase A2, primary Sj&ouml, gren syndrome, ACTIVATING-FACTOR-ACETYLHYDROLASE, CARDIOVASCULAR RISK-FACTORS, SUBCLINICAL ATHEROSCLEROSIS, DISEASE, A(2), PREVALENCE
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2022 Turkish League Against Rheumatism. All rights reserved.Objectives: This study aims to evaluate serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid intima-media thickness in primary Sjögren syndrome (pSS) as an indicator of atherosclerosis. Patients and methods: Between July 2019 and July 2020, a total of 33 female pSS patients (mean age: 44.5±11.2 years; range, 23 to 60 years) and 37 female age-and sex-matched healthy individuals (mean age: 40.9±7.2 years; range, 25 to 54 years) were included. Carotid intima-media thickness and serum Lp-PLA2 levels were measured in the patient and control groups. Results: The patients had a higher median serum Lp-PLA2 of 560 (range, 108 to 1,222) ng/mL vs. 328 (range, 0 to 1,280) ng/mL in the controls (p=0.024) and a similar mean intima-media thickness of carotid artery (0.64±0.14 mm vs. 0.62±0.15 mm, respectively; p=0.595). Serum Lp-PLA2 was positively correlated with platelet count (r=0.411, p=0.018) and negatively correlated with erythrocyte sedimentation rate (r=-0.409, p=0.018). The mean value of carotid intima-media thickness was positively correlated with disease duration (r=0.316, p=0.074) and was negatively correlated with the level of leucocyte (r=-0.458, p=0.007). Conclusion: Our study suggests that the patients of pSS have a potential risk of atherosclerotic cardiovascular disease, independent of traditional cardiovascular risk factors and disease severity.