Embryo Euploidy Rates and Reproductive Outcomes Following Ethanol Sclerotherapy, Laparoscopic Cystectomy, or No Intervention for Ovarian Endometriomas Prior to IVF with PGT-A: A Retrospective Cohort Study
Journal of Minimally Invasive Gynecology, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.jmig.2026.06.010
- Dergi Adı: Journal of Minimally Invasive Gynecology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
- Anahtar Kelimeler: Ethanol sclerotherapy, Euploidy rate, Laparoscopic cystectomy, Ovarian endometrioma, Preimplantation genetic testing for aneuploidy
- Ankara Üniversitesi Adresli: Evet
Özet
Study Objective: To compare embryo euploidy rates and reproductive outcomes among women with ovarian endometriomas who underwent ethanol sclerotherapy (EST), laparoscopic cystectomy, or expectant management prior to in vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A). Design: Retrospective cohort study. Setting: Tertiary referral center. Participants: A total of 554 infertile women with ovarian endometriomas (≥3 cm) who underwent IVF with PGT-A. Interventions: EST (n = 67), laparoscopic cystectomy (n = 138), or no intervention (n = 349). Measurements and Main Results: The primary outcome was blastocyst euploidy rate. Secondary outcomes included cumulative live birth rate (CLBR) and clinical pregnancy rate. Baseline characteristics were comparable, except for larger endometrioma size (p < .001) and higher prevalence of severe endometriosis (p = .013) in the EST group. Euploidy rates did not differ significantly (p = .129). CLBRs were 37.3%, 27.5%, and 30.1% in the EST, cystectomy, and no-intervention groups, respectively (p = .356). Multivariable and propensity score-matched analyses confirmed that the treatment group was not significantly associated with euploidy rate, CLBR, or clinical pregnancy. Conclusion: Endometrioma management strategy does not significantly influence embryo euploidy rates or reproductive outcomes in women undergoing IVF with PGT-A. The choice of pre-IVF endometrioma management may be guided by clinical considerations other than concerns regarding embryo chromosomal competence.