I-131 meta-iodobenzylguanidine and other diagnostic methods in neuroblastoma
Turkish Journal of Cancer, cilt.29, sa.2, ss.74-81, 1999 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 2
- Basım Tarihi: 1999
- Dergi Adı: Turkish Journal of Cancer
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.74-81
- Anahtar Kelimeler: Childhood tumors, I-131 MIBG, Neuroblastoma
- Ankara Üniversitesi Adresli: Evet
Özet
The aim of this study was to evaluate the correlation between I-131 meta-iodobenzylguanidine scintigraphy, urinary vanillymandelic acid levels and Tc-99m methylene diphosphonic acid bone scintigraphy in the diagnosis of neuroblastoma. We assessed the results of I-131 meta-iodobenzylguanidine used for differential diagnosis and follow-up of 16 children with solid tumors. I- 131 meta-iodobenzylguanidine was used for differential diagnosis in 15 patients, for re-evaluation following the treatment in four and for evaluation of the treatment in one patient. I-131 meta-iodobenzylguanidine scintigraphy yielded pathologic findings in all patients with neuroblastoma and was normal in other patients. The sensitivity and specificity of I-131 meta-iodobenzylguanidine scintigraphy was 100% for the diagnosis of neuroblastoma patients. The urinary vanillylmandelic acid levels were high in only two of the 10 patients with neuroblastoma. Tc-99m methylene diphosphonic acid bone scintigraphy was performed in 13 patients with solid tumor and found to be pathologic in 8 patients with neuroblastoma.