Akademik Veri Yönetim Sistemi
CANADIAN JOURNAL OF PLANT SCIENCE, cilt.89, sa.5, ss.953-959, 2009 (SCI-Expanded)
Sarikamis, G. 2009. Glucosinolates in crucifers and their potential effects against cancer: Review. Can. J. Plant Sci. 89: 953-959. There is growing interest in the health-promoting properties of cruciferous plant species, and people are urged to incorporate these plants into their diet to fight cancer. Cruciferous vegetables contain glucosinolates, the precursors of isothiocyanates, widely believed to protect humans against several forms of cancer. Iberin (1-isothiocyanato-3-methylsulphinylpropane) and sulforaphane (1-isothiocyanato-4-methylsulphinylbutane) are two isothiocyanates most abundant in broccoli that have been reported to protect against prostate, lung, breast and colon cancers. The aim of this review is to provide updated information on the importance of glucosinolates and their breakdown products (isothiocyanates) in delivering potential health benefits, and to describe the mechanism by which they act to provide these beneficial effects. Factors influencing the glucosinolate content of cruciferous vegetables, both from genetic and horticultural points of view, for future efforts to manipulate glucosinolate content of these vegetables are described. Finally, a brief summary of recent developments concerning crucifer intake and cancer prevention is provided.d