Construction of a sensitive electrochemical sensor based on 1T-MoS2 nanosheets decorated with shape-controlled gold nanostructures for the voltammetric determination of doxorubicin

ER E., ERK N.

MICROCHIMICA ACTA, cilt.187, sa.4, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 187 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s00604-020-4206-y
  • Dergi Adı: MICROCHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Analytical Abstracts, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, Pollution Abstracts, Civil Engineering Abstracts
  • Anahtar Kelimeler: Molybdenum disulfide, Transition metal dichalcogenides, Chemical exfoliation, Gold nanostructures, Modified electrode, Electrochemical determination, Doxorubicin, Anticancer drugs, Serum analysis, MOS2 NANOSHEETS, ELECTRODE, HYDROCHLORIDE, NANOPARTICLES, BIOSENSORS, FILM
  • Ankara Üniversitesi Adresli: Evet

Özet

An innovative and portable design to fabricate an electrochemical sensor based on metallic phase MoS2 (1T-MoS2) decorated with shape-dependent gold nanostructures for the determination of doxorubicin (DOX) is presented. In this context, homogenous and uniform single-crystal gold nanospheres (AuNSPs) and nanorods (AuNRDs) were firstly synthesized by seeded growth approach. Afterwards, AuNSPs and AuNRDs were anchored on 1T-MoS2 surfaces to construct the desired electrochemical sensing platform towards the DOX assay. 1T-MoS2 was exfoliated by metal intercalation process using NaK metal alloys. The structure and surface morphology of 1T-MoS2, AuNSPs, and AuNRDs were characterized by XPS, Raman, UV-vis, TEM, and SEM. The electrochemical behavior of DOX using various MoS2-based electrochemical sensors prepared on screen-printed electrode (SPE) was examined by cyclic voltammetry and adsorptive stripping differential pulse voltammetry. The electrocatalytic efficiency of AuNRDs on 1T-MoS2 was also compared with that of AuNSPs on 1T-MoS2, and it showed much better electrocatalytic activity towards the DOX. A nanocomposite prepared with AuNRDs and 1T-MoS2 on SPE (AuNRDs/1T-MoS2/SPE) exhibited a linear relationship between peak current and DOX concentration in the range 0.01-9.5 mu M with a detection limit of 2.5 nM. The AuNRDs/1T-MoS2/SPE was successfully applied to the sensitive and rapid determination of DOX in spiked human serum samples with satisfactory recoveries in the range 99.2-100.8%.