Selenium Levels in First-Degree Relatives of Diabetic Patients

ÖZKAYA M., ŞAHİN M., Cakal E., GİŞİ K., Bilge F., KILINÇ M.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.128, sa.2, ss.144-151, 2009 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 128 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s12011-008-8263-z
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.144-151
  • Anahtar Kelimeler: Selenium, First-degree relatives of type 2 diabetes, Hs-CRP, Homocysteine, INSULIN-RESISTANCE, SERUM SELENIUM, MYOCARDIAL-INFARCTION, TRACE-ELEMENTS, HEART-DISEASE, INFLAMMATION, RISK, MELLITUS, PLASMA, ASSOCIATION
  • Ankara Üniversitesi Adresli: Hayır

Özet

The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR) according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 +/- 5.9 vs 88.7 +/- 8.7 A mu g/dl, p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 A +/- 0.9 vs 0.63 A +/- 0.4 mg/dL, p < 0.0001; 2.07 A +/- 0.84 vs 1.51 A +/- 0.69, p < 0.0001; 9.26 A +/- 3.8 vs 6.8 A +/- 2.98 A mu U/MI, p < 0.0001; 15.7 A +/- 7.4 vs 11.5 A +/- 5.1 A mu mol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = - 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = -0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine levels in individuals with selenium levels < 80 A mu g/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels a parts per thousand yenaEuro parts per thousand 80 (n = 91; 1.23 A +/- 0.98 vs 0.81 A +/- 0.76 mg/dL, p < 0.003; 1.99 A +/- 0.88 vs 1.64 A +/- 0.74, p < 0.005; 15.0 A +/- 7.6 vs 12.9 A +/- 5.7 A mu mol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR.