Akademik Veri Yönetim Sistemi
Acta Pharmaceutica Turcica, cilt.38, sa.2, ss.43-46, 1996 (Scopus)
Acetaminophen that is an analgesic and antipyretic drug is widely being used. It is available in the dosage forms of tablet, syrup, elixir and suppository in Turkish drug market. The suppository dosage form is especially preferred by pediatric and geriatric clinics. In this study, seven different acetaminophen suppository batches of four different companies obtained from Turkish drug market were investigated. For this purpose the uniformity of weight and content, hardness, disintegration time and dissolution rate of the samples were investigated. The dissolution experiments were carried out according to the USP XXII basket method in the pH 7.2 phosphate buffer solution. The results were evaluated according to the related monographs of USP XXII and BP 1993. According to our results, one of the seven commercial acetaminophen suppositories in the market was found not to be in compliance with the USP XXII on drug content. When the dissolution of data of the samples was compared, only one could release 100% of the suppository content at the end of the 45 minutes. Three of them released the active substance among 90-100% on the contrary the other three samples remained under 75% at the end 90 minutes.