The in vitro oxidation of isomeric aromatic diazines to mono-N-oxides
Pharmaceutical Science Communications, cilt.4, sa.2, ss.117-124, 1994 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 4 Sayı: 2
- Basım Tarihi: 1994
- Dergi Adı: Pharmaceutical Science Communications
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.117-124
- Anahtar Kelimeler: HPLC, Metabolism of diazines, MS, N-oxidation, Species differences, TLC
- Ankara Üniversitesi Adresli: Evet
Özet
The biological oxidation of isomeric aromatic diazines (e.g. pyrazine, pyrimidine, pyridazine) has been studied using hepatic washed microsomes from various mammalian species. A mono-N-oxide was formed from each isomeric diazine with different efficiency. The N-oxide metabolites produced were characterized by comparison of their TLC and HPLC characteristics and their MS and UV spectra with those of authentic compounds.