Synthesis and antimicrobial activity of some new piperidinyl benzimidazoles

Kus C., GÖKER A. H., Ayhan G., Ertan R., Altanlar N., Akin A.

FARMACO, cilt.51, sa.6, ss.413-417, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 6
  • Basım Tarihi: 1996
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
  • Sayfa Sayıları: ss.413-417
  • Ankara Üniversitesi Adresli: Evet

Özet

A series of 2(4-methylpiperidin-1-yl)-1,5(6)-disubstituted-1H-benzimidazoles (1-18) were prepared through the reaction of 2-chloro (or 2-chloromethyl)-1H-benzimidazole derivatives with 4-methylpiperidine. For the preparation of the individual isomers, compounds 7, 9 and 18 were synthesized by a multistep procedure. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compound 3 and 4 exhibited the best antifungal activity.