Synthesis and antimicrobial activity of some new piperidinyl benzimidazoles
FARMACO, cilt.51, sa.6, ss.413-417, 1996 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 6
- Basım Tarihi: 1996
- Dergi Adı: FARMACO
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
- Sayfa Sayıları: ss.413-417
- Ankara Üniversitesi Adresli: Evet
Özet
A series of 2(4-methylpiperidin-1-yl)-1,5(6)-disubstituted-1H-benzimidazoles (1-18) were prepared through the reaction of 2-chloro (or 2-chloromethyl)-1H-benzimidazole derivatives with 4-methylpiperidine. For the preparation of the individual isomers, compounds 7, 9 and 18 were synthesized by a multistep procedure. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compound 3 and 4 exhibited the best antifungal activity.