Application of Nanomaterials in Development of Electrochemical Sensors and Drug Delivery Systems for Anticancer Drugs and Cancer Biomarkers

Ghalkhani M., Kaya S. I., Bakirhan N. K., Ozkan Y., ÖZKAN S. A.

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, cilt.52, sa.3, ss.481-503, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 52 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/10408347.2020.1808442
  • Dergi Adı: CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Geobase, MEDLINE, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.481-503
  • Anahtar Kelimeler: Analysis, anticancer drugs, drug delivery, electrochemical, nanomaterials, GLASSY-CARBON ELECTRODE, REDUCED GRAPHENE OXIDE, PASTE ELECTRODE, VOLTAMMETRIC DETERMINATION, GOLD NANOPARTICLES, DOXORUBICIN HYDROCHLORIDE, LIQUID-CHROMATOGRAPHY, TARGETED DELIVERY, SENSITIVE DETERMINATION, FE3O4 NANOPARTICLES
  • Ankara Üniversitesi Adresli: Evet

Özet

Worldwide occurrence of cancer has initiated a global effort for the development and production of various anticancer drugs. Unfortunately, high potential toxicity and mutagenic and carcinogenic side effects have been reported for most of the anticancer drugs, which cause many problems for the patient even at a slight dosage. Considering this, thanks to their outstanding features such as high sensitivity, selectivity, and cheapness, electrochemical methods have received much attention in the development of quick, precise, and reliable (bio) sensors for the monitoring of anticancer drugs and cancer biomarkers. Here, procedures and approaches presented for the development of modified electrodes based on nanomaterials employed for the anticancer drugs and cancer biomarkers sensing are reviewed. The analytical performance of the constructed electrodes including physical and electrochemical properties together with their figures of merits is highlighted. Nanomaterials offer excellent features for anticancer drugs. They improve multi-drug resistance, site-specificity and enhance efficient delivery. The premature degradation, preventing interaction with biological systems, absorption of the drugs into the selected tissues, controlling of the pharmacokinetic properties and skipping distribution profile can be performed with nanomaterials. In this review, detailed features of nanomaterials in anticancer drug delivery systems will be presented together with the application of nanomaterials in electrochemical sensors.