Synthesis and antiproliferative evaluation of novel 5-(4-methylpiperazin-1-yl)-2-phenyl-1H-benzimidazole derivatives

ALP M., Gurkan-Alp A. S., ÖZKAN T., SUNGUROĞLU A.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, cilt.70, sa.3-4, ss.79-85, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 3-4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1515/znc-2014-4189
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.79-85
  • Anahtar Kelimeler: AML, antiproliferative activity, apoptosis, benzimidazole, HL-60, BIOLOGICAL EVALUATION, APOPTOSIS, CELLS, ASSAY
  • Ankara Üniversitesi Adresli: Evet

Özet

A series of novel 5-(4-methylpiperazin-1-yl)-2-phenyl-1H-benzimidazoles (5-14) were synthesized and evaluated for their in vitro antiproliferative activities against the human leukemia cell line HL-60. Compounds 5-7 and 10-12 exhibited potent antiproliferative activities against this cell line. The quantitative analysis of apoptosis by flow cytometry demonstrated that the percentages of apoptotic HL-60 cells treated with compounds 5 and 10-12 were significantly higher than in the control.