Akademik Veri Yönetim Sistemi
EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.369, sa.3, ss.365-371, 1999 (SCI-Expanded)
The effect of single or combined administration of indomethacin and misoprostol on the exudate leukocyte count and thromboxane B-2, a stable metabolite of thromboxane A(2), and on the leukotriene B-4 level, as cyclooxygenase and lipoxygenase metabolites of arachidonic acid, was investigated in acute carrageenan-induced air pouch inflammation in rats. Administration of indomethacin (0.25 to 4 mg/kg) 1 h before carrageenan given by the orogastric route reduced the exudate leukocyte count and thromboxane B-2 level whereas it increased the exudate leukotriene B-4 level dose dependently. Administration of misoprostol, a synthetic prostaglandin E-1 analogue, (12.5 to 100 mu g/kg) twice daily for two days before carrageenan given by the orogastric route increased the exudate leukocyte count. Combined misoprostol and indomethacin did not change the effect of indomethacin alone on exudate leukocyte count. Misoprostol, when used alone, decreased exudate thromboxane B-2 level significantly. However, misoprostol did not change the exudate leukotriene B-4 level, while its combination with indomethacin prevented the indomethacin-induced increase in exudate leukotriene B-4 level. In conclusion, although misoprostol can be combined with non-steroidal anti-inflammatory drugs in many chronic inflammatory situations, our results indicate that misoprostol may also be combined with indomethacin in acute inflammation without producing any change on the antiinflammatory efficacy of indomethacin in rats. (C) 1999 Elsevier Science B.V. All rights reserved.