Akademik Veri Yönetim Sistemi
Pakistan Veterinary Journal, cilt.46, sa.2, ss.352-360, 2026 (SCI-Expanded, Scopus)
Campylobacteriosis is a leading zoonotic disease of global public health significance. Antibiotics are still the scientific and realistic way in the treatment of infectious bacterial diseases. However, AMR has been rapidly increasing worldwide due to overuse and misuse of antibiotics. In this study, C. jejuni and C. coli strains isolated from cecal samples of broiler, turkey, and cattle at the EPU level were used. The isolates were tested for susceptibility to critical and indicator antimicrobials based on ECOFF, and resistance mechanisms were analyzed. Resistance rates according to species for nalidixic acid, ciprofloxacin, and tetracycline among the analyzed Campylobacter isolates were identified as 75.9, 77.9, and 76.8% in broiler isolates; 80.7, 82.2, and 82.2% in turkey isolates; and 62.9, 63.8, and 75.2% in cattle isolates, respectively. In most strains, FQ resistance was primarily associated with a Thr-86-Ala mutation in the gyrA gene, while tetracycline resistance was linked to the tetO gene. Single point mutation in 23S rRNA gene (usually A2075G) or ermB gene was detected in a few strains with erythromycin resistance. In MDR strains, the cmeB membrane efflux gene was identified. In this study, the level of AMR and resistance mechanisms in indicator C. jejuni and C. coli strains isolated from food-producing animals demonstrated the need for urgent and sustainable collaborative action to monitor and control AMR. This study aimed to characterize the national antimicrobial resistance profiles of Campylobacter isolates from broilers, turkeys, and cattle, and to elucidate the underlying resistance mechanisms within a One Health framework.