Electrochemical fabrication of poly(L-alanine)-gold nanoparticle nanocomposite-modified electrode: application for determination and mechanism of antipsychotic drug olanzapine

Tuezuen, Uemmueye; Yildiz, Ceren; Eskiköy Bayraktepe, DİLEK; Polat, KAMRAN; Yazan, ZEHRA

doi:10.1007/s00706-022-03012-9

Electrochemical fabrication of poly(L-alanine)-gold nanoparticle nanocomposite-modified electrode: application for determination and mechanism of antipsychotic drug olanzapine

Atıf İçin Kopyala

Tuezuen U. N., Yildiz C., Eskiköy Bayraktepe D., Polat K., Yazan Z.

MONATSHEFTE FUR CHEMIE, cilt.154, ss.95-104, 2023 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 154
Basım Tarihi: 2023
Doi Numarası: 10.1007/s00706-022-03012-9
Dergi Adı: MONATSHEFTE FUR CHEMIE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
Sayfa Sayıları: ss.95-104
Anahtar Kelimeler: Poly(L-alanine), Gold nanoparticles, Electrodeposition, Olanzapine, Oxidation mechanism, Voltammetry, MODIFIED GOLD ELECTRODE, VOLTAMMETRIC DETERMINATION, QUANTUM DOTS, CARBON
Ankara Üniversitesi Adresli: Evet

Özet

This work presents a new electrochemical sensor based on poly(l-alanine) (l-Ala) (as a conducting polymer), and gold nanoparticles (AuNPs) coated with a pre-anodized pencil graphite electrode (pre-PGE). Electrosynthesis, preparation, and sensor characterization were studied by cyclic voltammetry, electrochemical impedance spectroscopy, and energy dispersive X-ray spectroscopy. Electrocatalytic activities of the sensor (AuNPs/poly(l-Ala)/pre-PGE) were compared with pre-PGE, poly(l-Ala)/pre-PGE. This polymer-nanoparticles-modified electrode was evaluated to determine olanzapine (OLA) by differential pulse voltammetry in Britton-Robinson buffer solution. The effect of each nanomaterial and pH was tested to investigate sensor performance. OLA's oxidation peak (0.850 V) was found linearly in the range of 0.271-1000.0 mu M with a detection limit of 0.081 mu M. The analytical applicability of the sensor was successfully carried out in pharmaceutical dosage forms, human urine, and human serum. Moreover, the electrochemical oxidation mechanism of the antipsychotic drug OLA was studied using cyclic voltammetry to understand its action mechanism and side effect.