Does thromboxane A(2) synthase inhibitor UK-38485 prevent the vasoconstrictor effects of endothelin-1 on rabbit basilar artery?

Baykaner M., Keskil I., Sencer H., Ilgit E., Ataoglu O., Ceviker N., ...More

ACTA NEUROCHIRURGICA, vol.141, no.3, pp.279-285, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 141 Issue: 3
  • Publication Date: 1999
  • Doi Number: 10.1007/s007010050299
  • Journal Name: ACTA NEUROCHIRURGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.279-285
  • Keywords: arachidonic acid, cerebral vasoconstriction, ultrastructure, vasoactive agents, EXPERIMENTAL SUBARACHNOID HEMORRHAGE, CEREBRAL VASOSPASM, SYNTHETASE INHIBITOR, BARRIER DISRUPTION, ANGIOTENSIN-II, ILOPROST, WALL, PROSTACYCLIN, INJECTION, BLOOD
  • Ankara University Affiliated: No

Abstract

Prevention of the production of thromboxane A(2) -a potent vasoconstrictor and aggregating metabolite of arachidonic acid- or infusion of the stable analogues of prostacyclin -which is another cyclooxygenase metabolite of arachidonic acid- has been shown to be beneficial in cerebral vasoconstriction. Endothelin-l, a peptide derived from endothelial cells, has been shown to induce a long-lasting cerebral vasoconstriction both in vivo and in vitro. The purpose of this study was to investigate the role of a novel thromboxane A(2)-synthase inhibitor UK 38485 on the acute vascular and morphological effects of Endothelin-l applied intra-arterially on rabbit basilar arteries.