Vector vaccination and vector targeted chemotherapy in solid tumors

AKBULUT H., Tang Y., Deisseroth A.

JOURNAL OF BUON, cilt.14, 2009 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14
  • Basım Tarihi: 2009
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: adenoviral vectors, cytosine deaminase, gene therapy, tumor vaccines, SUICIDE GENE-THERAPY, L-PLASTIN PROMOTER, CYTOSINE DEAMINASE, DENDRITIC CELLS, PHASE-I, RECURRENT HEAD, CANCER, ADENOVIRUS, OVARIAN, 5-FLUOROURACIL
  • Ankara Üniversitesi Adresli: Evet

Özet

Gene therapy is one of the promising treatment modalities in cancer therapy. The current gene therapy modalities are mainly focused on the introduction of suppressed tumor suppressor genes into cancer cells, modulation of anti-tumoral immune response, and the suicide gene therapy by introducing pro-drug-activating enzyme genes into the tumor cells. Currently, various gene therapy trials arc, being conducted in cancer patients. However the early results of these trials conducted so far are not so encouraging. Combination of gene therapy strategies with conventional treatment modalities such as chemotherapy, immunotherapy or radiotherapy has yielded encouraging results in experimental models and early clinical trials.