Allogeneic peripheral blood stem cell transplantation for severe aplastic anemia

GÜRMAN G., Celebi H., Ustun C., Arat M., Ilhan O., Ozcan M., ...Daha Fazla

THERAPEUTIC APHERESIS, cilt.5, sa.1, ss.54-57, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 1
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1046/j.1526-0968.2001.005001054.x
  • Dergi Adı: THERAPEUTIC APHERESIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.54-57
  • Anahtar Kelimeler: severe aplastic anemia, allogeneic peripheral food stem cell transplantation, BONE-MARROW TRANSPLANTATION, COLONY-STIMULATING FACTOR
  • Ankara Üniversitesi Adresli: Evet

Özet

Allogeneic peripheral blood Stem cell transplantation (PBSCT) is rarely applied for the treatment of severe aplastic anemia (SAA) because of questionable durablility of graftment and increased risk of P host disease (GVHD). We performed allogeneic PBSCT in 3 SAA patients from their human leukocyte antigen (HLA)-identical siblings. One received bone marrow after conditioning with cyclophoshamide (Cy) plus antithymocyte globulin. He had a second transplant with peripheral blood stem cells from the original donor because of a graft failure (GF). Two other patients received PBSCT as a first option. with Cy as the only conditioning drug. The 3 patients received short-term methotrexate and cyclosporine as a postgrafting, immunosupression. In the latter 2 cases, no GF has been observed, and a successful and complete hematological recovery was achieved and maintained for 28 and 25 months. respectively, In conclusion, PBSCT provides a quick and complete hematological recovery in SAA patients.