The comparative effects of recombinant human erythropoietin and darbepoetin-alpha on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit

Kertmen H., Gurer B., Yilmaz E. R., Arikok A. T., Kanat M. A., ERGÜDER B. İ., ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.156, sa.5, ss.951-962, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 156 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s00701-014-2008-x
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.951-962
  • Anahtar Kelimeler: Darbepoetin alpha, Erythropoietin, Rabbit, Subarachnoid hemorrhage, Vasospasm, IN-VIVO EVIDENCE, NITRIC-OXIDE, ENDOTHELIAL-CELLS, CEREBROSPINAL-FLUID, OXIDATIVE STRESS, BRAIN-TISSUE, DOUBLE-BLIND, L-ARGININE, ISCHEMIA, ARGINASE
  • Ankara Üniversitesi Adresli: Evet

Özet

Darbepoetin alpha is a hypersialylated analogue of erythropoietin effective for activating erythropoietin-receptors. This study investigated the vasodilator and neuroprotective effects of darbepoetin alpha on an experimental subarachnoid hemorrhage model and compared it with erythropoietin.