The comparative effects of recombinant human erythropoietin and darbepoetin-alpha on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit

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Kertmen H., Gurer B., Yilmaz E. R., Arikok A. T., Kanat M. A., ERGÜDER B. İ., ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.156, sa.5, ss.951-962, 2014 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 156 Sayı: 5
• Basım Tarihi: 2014
• Doi Numarası: 10.1007/s00701-014-2008-x
• Dergi Adı: ACTA NEUROCHIRURGICA
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.951-962
• Anahtar Kelimeler: Darbepoetin alpha, Erythropoietin, Rabbit, Subarachnoid hemorrhage, Vasospasm, IN-VIVO EVIDENCE, NITRIC-OXIDE, ENDOTHELIAL-CELLS, CEREBROSPINAL-FLUID, OXIDATIVE STRESS, BRAIN-TISSUE, DOUBLE-BLIND, L-ARGININE, ISCHEMIA, ARGINASE
• Ankara Üniversitesi Adresli: Evet

Özet

Darbepoetin alpha is a hypersialylated analogue of erythropoietin effective for activating erythropoietin-receptors. This study investigated the vasodilator and neuroprotective effects of darbepoetin alpha on an experimental subarachnoid hemorrhage model and compared it with erythropoietin.