Effects of oxaliplatin and 5-fluorouracil on the healing of colon anastomoses

ERSOY P. E., AKBULUT H., Moray G.

SURGERY TODAY, vol.39, no.1, pp.38-43, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1007/s00595-008-3795-6
  • Journal Name: SURGERY TODAY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.38-43
  • Keywords: Wound healing, Oxaliplatin, 5-Fluorouracil, EARLY POSTOPERATIVE 5-FLUOROURACIL, COLORECTAL-CANCER, ADJUVANT THERAPY, INTERFERON, STRENGTH, ACID
  • Ankara University Affiliated: Yes

Abstract

Oxaliplatin (OX) and 5-fluorouracil (5-FU) are the most widely used chemotherapeutic agents in the adjuvant treatment of colon cancer. Although the early initiation of adjuvant chemotherapy can improve the outcome of surgery, it carries potentially fatal risks. This experimental study investigates the effects of 5-FU and OX on colon anastomoses.