Preparation and in vitro evaluation of modified release ketoprofen microsponges

ÇOMOĞLU T., Gönül N., Baykara T.

Farmaco, cilt.58, sa.2, ss.101-106, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0014-827x(02)00007-1
  • Dergi Adı: Farmaco
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.101-106
  • Anahtar Kelimeler: Ketoprofen, Microsponges, Modified release, Quasi-emulsion solvent diffusion method
  • Ankara Üniversitesi Adresli: Evet

Özet

Microsponges containing ketoprofen and Eudragit RS 100 were prepared by quasi-emulsion solvent diffusion method. The effects of different mixing speeds, drug-polymer ratios, solvent-polymer ratios on the physical characteristics of the microsponges as well as the in vitro release rate of the drug from the microsponges were investigated. All the factors studied had an influence on the physical characteristics of the microsponges. In vitro dissolution results showed that the release rate of ketoprofen was modified in all formulations. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.