Coenzyme Q and relation with diseases Koenzim Q ve Hastaliklar ile Ilişkisi
Ataturk Universitesi Veteriner Bilimleri Dergisi, vol.11, no.2, pp.247-253, 2016 (Scopus, TRDizin)
- Publication Type: Article / Review
- Volume: 11 Issue: 2
- Publication Date: 2016
- Doi Number: 10.17094/avbd.96215
- Journal Name: Ataturk Universitesi Veteriner Bilimleri Dergisi
- Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.247-253
- Keywords: Antioxidative, Coenzyme Q, Disease
- Open Archive Collection: AVESIS Open Access Collection
- Ankara University Affiliated: Yes
Abstract
Coenzyme Q (2- methyl - 5, 6 dimethoxy- 1, 4 -benzoquinone, KoQ, Ubiquinone, UQ) is present in all cells and cellular membranes and plays a key role in the mitochondrial respiratory chain and a vital molecule for cellular metabolism. Coenzyme Q has strong lipophilic antioxidant properties which enables this coenzyme to protect lipoproteins and cellular membranes. The earliest studies mainly focused on the redox function of Coenzyme Q; however, for the last 20 years, various functions have now been identified. The latest research has investigated its various additional roles which include: the antioxidative system, effects on monocytes and lymphocytes, endothelial function, cell signalling and gene expression. Coenzyme Q levels vary depending on the age and diseases status of the organism. Its importance during disease diagnosis and in the treatment process has been highlighted. Coenzyme Q is mostly associated with diseases such as cardiovascular diseases, degenerative muscle diseases, bone diseases, cancer, diabetes and neurodegenerative diseases (Huntington's disease, Parkinson's disease, Alzheimer disease). It is therefore a very important parameter which is associated with an organism health or disease state. In this review, up-to-date data regarding the known functions of coenzyme Q and its connection with various diseases are presented.