Comparison of adhesive properties of five different prosthetic materials used in hernioplasty

Kayaoglu H., Ozkan N., Hazinedaroglu S. M., Omer F., ERKEK A. B., Koseoglu R.

JOURNAL OF INVESTIGATIVE SURGERY, cilt.18, sa.2, ss.89-95, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/08941930590926357
  • Dergi Adı: JOURNAL OF INVESTIGATIVE SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.89-95
  • Anahtar Kelimeler: adhesion, hernia, fibrosis, inflammation, polyester, polyglactin, polypropylene, polytetrafluoroethylene, ABDOMINAL-WALL DEFECTS, EXPANDED POLYTETRAFLUOROETHYLENE, POLYPROPYLENE MESH, HERNIA REPAIR, INTRAPERITONEAL MESH, INITIAL-EXPERIENCE, INCISIONAL HERNIAS, MODEL, PREVENTION, COMPOSITE
  • Ankara Üniversitesi Adresli: Evet

Özet

This experimental study was designed to assess and to compare intra-abdominal adhesions following the use of five commercially available prosthetic mesh grafts in the repair if abdominal wall defects. Sixty Wistar albino rats were randomly divided into six groups ( n= 10). A 2 x 1 cm defect at abdominal wall was created and defects were closed either primarily or with one of the following prosthetic mesh grafts: monofilament polypropylene, polytetrafluoroethylene, sodium hyaluronate/ carboxymethylcellulose- coated polypropylene, polypropylene/ polyglactin 910 composite, or resorbable hydrophilic collagencoated multifiber polyester. The severity of adhesions was graded, tensile strengths of adhesions were measured, and histopathological grades of inflammation and fibrosis were evaluated. Polypropylene mesh resulted in more adhesion formation in comparison to primary repair and other grafts used in this study, except polypropylene/ polyglactin 910 composite mesh. In addition, the highest tensile strength of omental adhesions was detected in the polypropylene group (chi(2) = 26.249; p =.0001). Polyester composite mesh caused the least adhesion formation among the groups. Sodium hyaluronate/ carboxymethylcellulose-coated polypropylene and polyester composite meshes revealed the highest fibrosis scores (chi(2) = 50.776; p =.0001). The highest inflammatory activity was detected in the polytetrafluoroethylene mesh group (chi(2) = 16.564; p =.005). Thus, sodium hyaluronate/ carboxymethylcellulose-coated polypropylene and polytetrafluoroethylene meshes following polyester composite mesh were the minimal adhesion-forming grafts in this study. Disadvantages of the polytetrafluoroethylene mesh were lower fibrotic activity and higher inflammatory reaction to the graft.