Effects of selective cyclooxygenase enzyme inhibitors on lipopolysaccharide-induced dual thermoregulatory changes in rats

Dogan M., Ataoglu H., Akarsu E. S.

BRAIN RESEARCH BULLETIN, cilt.57, sa.2, ss.179-185, 2002 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0361-9230(01)00739-0
  • Dergi Adı: BRAIN RESEARCH BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.179-185
  • Anahtar Kelimeler: hypothermia, fever, valeryl salicylate, SC-58236, tumor necrosis factor-alpha, PROSTAGLANDIN ENDOPEROXIDE SYNTHASE, TUMOR-NECROSIS-FACTOR, BODY-TEMPERATURE, FEBRILE RESPONSE, BACTERIAL LIPOPOLYSACCHARIDE, INDUCIBLE CYCLOOXYGENASE, MESSENGER-RNA, INDUCED FEVER, BRAIN, EXPRESSION
  • Ankara Üniversitesi Adresli: Evet

Özet

The effects of selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors (valeryl salicylate and SC-58236, respectively) on Escherichia coli O111:B4 lipopolysaccharide (LPS)-induced dual thermoregulatory changes and serum tumor necrosis factor-alpha elevation were investigated in rats. LPS (50 mug/kg, intraperitoneal) produced an initial hypothermia that was then followed by fever. Serum tumor necrosis factor-alpha levels elevated at the initial phase of hypothermia. Valeryl salicylate injections (20, 40, and 80 mg/kg, subcutaneous [s.c.]) completely inhibited hypothermia without any effect on the elevated serum tumor necrosis factor-alpha levels and on the subsequent fever. On the other hand, SC-58236 injections (10, 20, and 40 mg/kg, s.c.) only partially abolished the hypothermia. SC-58236 had no effect on the initiation of fever, however completely inhibited the maintenance of fever. The serum tumor necrosis factor-alpha elevation was not reduced by SC-58236 treatment. The combination of valeryl salicylate and SC-58236 also failed to inhibit the initiation of fever. These findings suggest that cycloxygenase-1 may have a predominant role for the development of LPS-induced hypothermia, but cyclooxygenase-1 does not seem to be involved in the mediation of LPS-induced fever. Meanwhile, cyclooxgenase-2 may be critical for the late phase rather than the initiation of the fever response in rats. (C) 2002 Elsevier Science Inc.