Development of reconstitutable suspensions containing diclofenac sodium-loaded microspheres for pediatric delivery

ÖZ U. C., DEVRİM GÖKBERK B., BOZKIR A., Canefe K.

JOURNAL OF MICROENCAPSULATION, cilt.32, sa.4, ss.317-328, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/02652048.2015.1017616
  • Dergi Adı: JOURNAL OF MICROENCAPSULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.317-328
  • Anahtar Kelimeler: Diclofenac sodium, Eudragit RS, microsphere, reconstitutable pediatric suspension, solid-in-oil-in-water emulsion method, IN-VITRO RELEASE, XANTHAN GUM, SOLVENT EXTRACTION/EVAPORATION, FORMULATION PARAMETERS, PLGA MICROPARTICLES, ACID MICROSPHERES, DRUG-DELIVERY, LACTIC ACID, STABILITY, OPTIMIZATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Effective clinical utilisation of non-steroidal anti-inflammatory drugs, such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration. The objective of this work was to develop reconstitutable pediatric suspensions of DS-loaded microspheres prepared with an acrylic polymer (Eudragit RS) for improved pediatric delivery of DS. The microspheres were prepared by the water-in-oil-in-water or solid-in-oil-in-water emulsion techniques. Enviromental scanning electron microscopy observations clearly showed that microspheres have spherical shape. The drug entrapment efficiency of these microspheres was found 47.96 +/- 0.79% to 88.57 +/- 0.59% and their average particle sizes were 23.94-60.78 mu m, which are within the desired range for the development of suspension formulation. The in vitro dissolution indicated prolonged sustained release of DS over 8 h. The results of preliminary characterisation studies of suspensions show that a liquid pharmaceutical preparation for oral administration capable of providing a sustained release of DS was successfully obtained.