Voltammetric determination of salbutamol based on electrochemical oxidation at platinum and glassy carbon electrodes
Turkish Journal of Chemistry, cilt.22, sa.2, ss.175-182, 1998 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 2
- Basım Tarihi: 1998
- Dergi Adı: Turkish Journal of Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.175-182
- Anahtar Kelimeler: salbutamol, platinum and glassy carbon electrodes, pharmaceutical dosage forms, voltammetry, SPECTROPHOTOMETRIC METHOD, LIQUID-CHROMATOGRAPHY, GAS-CHROMATOGRAPHY, HUMAN PLASMA, SULFATE, DRUGS, ALBUTEROL, COLUMNS, URINE
- Ankara Üniversitesi Adresli: Evet
Özet
The oxidative behavior of salbutamol was studied as a function of pH at platinum and activated glassy carbon electrodes. Between pH 1.9 and 12.0, the drug was characterized by a single oxidation step at both electrodes. The process was found to be dependent on the nature and the pH of the supporting elctrolyte. The procedure yielded a linear concentration range of 1 × 10-4 to 1 × 10-3 M and 2 × 10-5 to 1 × 10-3 M in 0.2 M sulphuric acid and a phosphate buffer of pH 6, at platinum and glassy carbon electrodes, respectively. The method was used for the determination of salbutamol in pharmaceutical dosage forms.