Synthesis and antimicrobial evaluation of some new 2-(2-(p-chlorophenyl) benzimidazol-1-yl methyl)-5-substituted amino-[1,3,4]-thiadiazoles

Kilcigil G., Kus C., Altanlar N., Ozbey S.

TURKISH JOURNAL OF CHEMISTRY, vol.29, no.2, pp.153-162, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2005
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.153-162
  • Keywords: benzimidazoles, thiadiazoles, antimicrobial activity, X-ray, ANTIALLERGIC AGENTS, DERIVATIVES, 1,3,4-THIADIAZOLE, INDOLE, 1,2,4-TRIAZOLE
  • Ankara University Affiliated: Yes

Abstract

Some 2-(2-(p-chlorophenyl)benzimidazol-1-ylmethyl)-5-substituted amino-[1,3,4]-thiadiazoles were synthesized and their in vitro antimicrobial activities were tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans and Candida krusei. Compounds 1b and 12b which possess remarkable activity against C. albicans and marginal activity against C. krusei were found to be the most active compounds in this series. Single crystal X-ray diffraction analysis was performed for compound 8b.