Determination of Dysregulated miRNA Expression Levels by qRT-PCR after the Application of Usnic Acid to Breast Cancer

Tanman U., Yangin S., CANSARAN DUMAN D.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.20, sa.5, ss.548-558, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1871520619666190923163552
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.548-558
  • Anahtar Kelimeler: Usnic acid, miRNAs, qRT-PCR, breast cancer, secondary metabolite, prognosis, ENDOPLASMIC-RETICULUM, TARGET, SUPPRESSOR, GENE, APOPTOSIS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background and Purpose: Breast cancer still remains to be one of the most threatening cancer types in women. Recent studies have allowed scientists to better investigate the potential use of natural compounds in the treatment of breast cancers. Usnic acid is a secondary metabolite extracted from lichen species and has many biological activities. The response of microRNAs regulated by drug molecules may provide useful diagnostic and prognostic biomarkers, as well as potential therapeutics for breast cancers. Although the aberrant expression of microRNAs was observed after drug treatment, the regulatory mechanisms remain partially known. Micro RNAs (miRNAs) play an important role in gene regulation at the post-transcriptional level.