Are drug provocation tests still necessary to test the safety of COX-2 inhibitors in patients with cross-reactive NSAID hypersensitivity?
ALLERGOLOGIA ET IMMUNOPATHOLOGIA, vol.41, no.3, pp.181-188, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 41 Issue: 3
- Publication Date: 2013
- Doi Number: 10.1016/j.aller.2012.03.006
- Journal Name: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.181-188
- Keywords: Drug hypersensitivity, Drug provocation tests, Alternative drugs, Nimesulide, Meloxicam, Aspirin hypersensitivity, Aspirin intolerance, NSAID cross-reactivity, Predictive factors, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, LONG-TERM TOLERABILITY, CYCLOOXYGENASE-2 INHIBITORS, GENERAL-CONSIDERATIONS, ANALGESIC INTOLERANCE, CUTANEOUS REACTIONS, SENSITIVE PATIENTS, ADVERSE-REACTIONS, INDUCED URTICARIA, ASPIRIN
- Ankara University Affiliated: Yes
Abstract
Background: COX-2 inhibitors are safe alternatives in patients with cross-reactive non-steroidal anti-inflammatory drug (NSAID) hypersensitivity. These drugs are recommended to these patients after negative drug provocation tests (DPTs). However, cumulative data on encouraging results about the safety of COX-2 inhibitors in the majority of these patients bring the idea as to whether a DPT is always mandatory for introducing these drugs in all patients with cross-reactive NSAID hypersensitivity.