Are drug provocation tests still necessary to test the safety of COX-2 inhibitors in patients with cross-reactive NSAID hypersensitivity?

ÇELİK G. E., Erkekol F. O., AYDIN Ö., DEMİREL Y. S., Misirligil Z.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, cilt.41, sa.3, ss.181-188, 2013 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.aller.2012.03.006
  • Dergi Adı: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.181-188
  • Anahtar Kelimeler: Drug hypersensitivity, Drug provocation tests, Alternative drugs, Nimesulide, Meloxicam, Aspirin hypersensitivity, Aspirin intolerance, NSAID cross-reactivity, Predictive factors, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, LONG-TERM TOLERABILITY, CYCLOOXYGENASE-2 INHIBITORS, GENERAL-CONSIDERATIONS, ANALGESIC INTOLERANCE, CUTANEOUS REACTIONS, SENSITIVE PATIENTS, ADVERSE-REACTIONS, INDUCED URTICARIA, ASPIRIN
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: COX-2 inhibitors are safe alternatives in patients with cross-reactive non-steroidal anti-inflammatory drug (NSAID) hypersensitivity. These drugs are recommended to these patients after negative drug provocation tests (DPTs). However, cumulative data on encouraging results about the safety of COX-2 inhibitors in the majority of these patients bring the idea as to whether a DPT is always mandatory for introducing these drugs in all patients with cross-reactive NSAID hypersensitivity.