Akademik Veri Yönetim Sistemi
Scientia Pharmaceutica, cilt.64, sa.2, ss.173-183, 1996 (SCI-Expanded)
In this paper, determination of paracetamol and hyoscine N-butyl bromide in their binary mixture was realized by precipitating hyoscine N-butyl bromide with ammonium reineckate at pH 6,0 selectively and reading the absorbance of the solution of the precipitate in acetone at 525.0 nm for hyoscine N-butyl bromide by measuring the dA/dλ values at 254.5 nm in the first derivative spectra of the remaining solution for paracetamol. The relative standard deviation of the method was found to be 0.90% for hyoscine N-butyl bromide and 0.10% for paracetamol. Recoveries were found to be 98.3% and 99.8% for hyoscine N-butyl bromide and paracetamol respectively. The method has been succesfully applied to a film-coated tablets containing hyoscine N-butyl bromide and paracetamol.