Akademik Veri Yönetim Sistemi
TNRD 2021, İstanbul, Türkiye, 17 - 21 Şubat 2021, ss.90
Objective: Neurofibromatosis type I (NF1) is a multisystemic genetic disease in which optic nerve
gliomas (ONG) develops frequently. Despite the ONGs are WHO grade I tumors, they may cause
progressive vision loss, so early diagnosis is mandatory. The purpose of this study is to evaluate the
optic nerve thickness and the presence of tortuosity in patients with NF1 with or without ONG and
control subjects and to be able to make more objective criteria for the diagnosis of ONG.
Materials And Methods: MR images of fourty-one patients with NF1 (82 optic nerves) and age-gender
matched 41 control subjects (82 optic nerves) were evaluated retrospectively. A pediatric radiologist
evaluated the optic nerve thickness at multiple locations. Also the presence of the tortuosity and the
subarachnoid dilatation was reported. Kruskal-Wallis and Bonferroni post-hoc analysis was used.
Results: The mean diameter of the optic nerve was statistically significant (p<0.05) in patients with NF1
with OSG compared with those with NF1 without OSG and with control subjects at all locations except
chiasmatic segments. Also tortuosity was more common in the NF1 with OSG compared with NF1
without OSG and control group (%70, %38 and %25.7, respectively).
Conclusion: The knowledge of normal values of optic nerves in pediatric patients and effective use of
optic nerve thickness and tortuosity in the diagnosis of ONG may reduce the use of contrast agents
and related side effects