Low-cost voltammetric sensor based on reduced graphene oxide anchored on platinum nanoparticles for robust determination of Favipiravir in real samples

Bouali W., ERK N., Kholafazadehastamal G., Naser M., TIRIS G.

Diamond and Related Materials, cilt.131, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 131
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.diamond.2022.109609
  • Dergi Adı: Diamond and Related Materials
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, INSPEC, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: Covid-19, Favipiravir, Graphene oxide, Metal nanoparticles, Pharmaceutical sample, ELECTROCHEMICAL SENSOR, COMPOSITE
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2022 Elsevier B.V.This research describes a simple, sensitive, and disposable modified glassy carbon electrode constructed using platinum nanoparticles anchored on reduced graphene oxide nanocomposite as a conductive modifier (Pt@rGO/GCE) to detect an anti-coronavirus drug, Favipiravir (FAV). The as-synthesized nanocomposite was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), and atomic force microscopy (AFM). Under optimized conditions, the square wave voltammetry (SWV) method was used to determine trace amounts of FAV in real samples. The proposed electrode demonstrated a wide linear concentration range of 3.16 to 100.0 μM with a low detection limit (LOD) of 2.46 μM. Moreover, the developed electrode showed outstanding selectivity in the presence of several interferences with high repeatability and reproducibility. Finally, the developed electrode was applied to detect FAV in human plasma and pharmaceutical samples.