IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines

Creative Commons License

Zhu X., Mulcahy L. A., Mohammed R. A. A., Lee A. H. S., Franks H. A., Kilpatrick L., ...More

BREAST CANCER RESEARCH, vol.10, no.6, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1186/bcr2195
  • Journal Name: BREAST CANCER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Ankara University Affiliated: No

Abstract

Introduction IL-17 plays an important role in autoimmunity, promoting autoimmunity, inflammation and invasion in multiple sclerosis, rheumatoid arthritis and type I diabetes. The role of IL-17 in cancer is unclear, however, as there are few studies examining IL-17 protein expression in cancer. We therefore examined IL-17 protein expression in human breast cancer and modelled its potential biological significance in vitro.