POLYMORPHISM IN THE P2X7 GENE INCREASES SUSCEPTIBILITY TO EXTRAPULMONARY TUBERCULOSIS IN TURKISH CHILDREN
PEDIATRIC INFECTIOUS DISEASE JOURNAL, cilt.29, sa.8, ss.779-782, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 8
- Basım Tarihi: 2010
- Doi Numarası: 10.1097/inf.0b013e3181d9932e
- Dergi Adı: PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.779-782
- Anahtar Kelimeler: childhood, extrapulmonary tuberculosis, single nucleotide polymorphism, P2X(7) GENE, RECEPTOR, PROTEIN
- Ankara Üniversitesi Adresli: Evet
Özet
The P2X7 gene polymorphisms have been linked to increased risk for pulmonary and extrapulmonary tuberculosis in some populations. In this study, the genotype and allelic frequencies 1513A -> C variant within the P2X7 gene was significantly higher than in the healthy controls (P = 0.035, P = 0.041). This is the first study demonstrating that the 1513A -> C polymorphism is associated with extrapulmonary tuberculosis in children.